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KMID : 0383019740050020027
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Alumni Bulletin of Internal Medicine
1974 Volume.5 No. 2 p.27 ~ p.35
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Clinical Observation on the Treatment of j Chloramphenicol, Bactrim and Penbritin in Typhoid Fever
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徐東震/Suh, D.J.
張麟/池英一/魯炳鎬/Chang, R./Chi, Y.I./Ro, B.H.
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Abstract
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The purpose of this study was to compare the relative efficacy of chloramphenicol (continuous or intermittent therapy), Ampicillin and Bactrini in the treatment of Typhoid fever. We also studied treatment failures, drug complications, clinical relapse and carrier rate in these therapy groups. The results were as follows:
1. The mean values for the duration of the chlo-ramphenicol and Ampicillin therapy before the first afebrile day were 5.48 and 5.78 days respectively, whereas for Bactrim, the value was 3.6 days. The response appears to be more rapid with Bactrim than with ch1horainphenicol and Ampicillin.
2. In patient with positive stool culture they req-uired 6.4 days to become negative for stool culture with continuous chloramphenicol therapy. The mean values for Bactrim and Ampicillin groups were 5.6 and 7 days respectively, whereas for intermittent chloramphenicol group, the value was 11.9 days.
3. There were no development of carriers in any of the these drug groups.
4. There were 2 relapses in the Bactrim group, but none in the chloramphenicol and Ampicillin groups.
5. There was one drug adverse reaction(urticaria) each in the Ampicillin and Bactrim groups. But none in the chloramphenicol group.
6. There were two treatment failures in the Am-picillin. group, and none in the chloramphenicol and Bactrim groups.
7. During the course of illness, the abnormalities of liver function tests were progressively getting worse in the chloramphenicol therapy group, whereas for the Bactrim group, they became completely normal around 10 days after therapy.
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